Modeling of Dose-Response Relationships
نویسندگان
چکیده
منابع مشابه
Modeling of dose-response relationships.
The main dose-response models for chronic toxicity are considered. For dichotomous response, the log probit, multi-hit, and multistage models are presented. For time-to-occurrence response, the log-normal and three variations of multistage models are presented. Finally, the Cornfield hockey-stick model is considered, and, for low-dose extrapolation, it is suggested that response be taken to be ...
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We review the experimental evidence for various shapes of dose-response relationships for carcinogens and summarize those experiments that give the most information on relatively low doses. A brief review of some models is given to illustrate the shapes of dose-response curve expected from them. Our major interest is in the use of dose-response relationships to estimate risks to humans at low d...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1981
ISSN: 0091-6765
DOI: 10.2307/3429186